The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for GxE research.

摘要: Schizophrenia is a devastating mental disorder. The level of risk in the general population sustained by persistence social, environmental and biological factors, as well their interactions. Socio-environmental factors for schizophrenia are established robust. same can belatedly be said genetic Recent progress genetics primarily fuelled genome-wide association, which able to leverage substantial proportions additional explained variance previously classified ‘missing’. Here, we provide an outline emerging landscape demonstrate how this knowledge turned into simple empirical measure risk, known polygenic score. We highlight statistical framework used assess clinical potential new score finally, draw relevance discuss implications study gene–environment interaction.