Impact of COMT genotype on cognition in schizophrenia spectrum patients and their relatives.
作者： Pilar Lopez-Garcia , Leslie Young Espinoza , Patricio Molero Santos , Juan Marin , Felipe Ortuño Sanchez-Pedreño
DOI: 10.1016/J.PSYCHRES.2012.09.043
关键词:
摘要: Cognitive impairment in schizophrenia is a core feature and seems to be related mainly dopaminergic dysfunction the prefrontal cortex (PFC). The functional polymorphism Val158Met of COMT (catechol-O-methyltransferase) gene could mediate relationship between cognition dopamine activity PFC. present study tested influence this on cognitive performance spectrum patients their relatives, using some subtests neuropsychological battery, Measurement Treatment Research Improve Cognition Schizophrenia (MATRICS) Consensus Battery, evaluated impact specific function neuroscience paradigm. A Group 74 disorder patients, 48 relatives 67 controls performed MATRICS Battery. In addition, 40 26 63 Dot Pattern Expectancy Task (DPX) context processing. For no differences any domains were found according genotype. DPX task was sensitive genotype effects as well relatives. Context processing deficits may mediated by more relevant tasks function. These results should replicated larger samples.
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