Isolation and characterization of cholecystokinin‐58 (CCK‐58) from porcine brain
作者： Kazuhiko Tatemoto , Hans Jörnvall , Sirkka Siimesmaa , Gunnel Halldén , Viktor Mutt
DOI: 10.1016/0014-5793(84)81175-8
关键词:
摘要: A 58-residue peptide has been isolated from extracts of porcine brain and shown to be an N-terminally extended cholecystokinin (CCK). The amino acid sequence this is: Ala-Val-Gln-Lys-Val-Asp-Gly-Glu-Ser-Arg-Ala-His-Leu-Gly-Ala-Leu-Leu-Ala- Arg-Tyr- Ile-Gln-Gln-Ala-Arg-Lys-Ala-Pro-Ser-Gly-Arg-Val-Ser-Met-Ile-Lys-Asn-Leu- Gln-Ser- Leu-Asp-Pro-Ser-His-Arg-Ile-Ser-Asp-Arg-Asp-Tyr(SO3)-Met-Gly-Trp-Met-Asp -Phe-NH2. was found induce contraction the guinea-pig gallbladder, but pattern action seemed differ those CCK-8 CCK-33.
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