Matrices containing NaCMC and HPMC 1. Dissolution performance characterization.

摘要: In this study hydroxypropylmethylcellulose (HPMC) and sodium carboxymethylcellulose (NaCMC) were used as polymeric carriers to improve controlled release performances of matrix tablets containing a soluble drug. The drug behaviour the systems these two polymers mixture each material separately was investigated. To evaluate effect dissolution medium pH, on performance, tests conducted at pH 1, 4.5 6.8. vitro studies demonstrated that cellulose derivatives enables better control profiles 6.8 both in term rate mechanism. Texture analysis swollen helps understand kinetic fact, results obtained confirm gel, which is characterized by high strength consistence less susceptible erosion chains disentanglement mechanism mainly governed diffusion. On contrary, gels, show low texture, have resistance fluid action active molecule manly due polymer relaxation moving delivery towards an erosion/relaxation