Characterization of a potent inhibitor of platelet aggregation and release reaction isolated from (Garlic)

摘要: Abstract When added to platelet-rich plasma, aqueous extracts of garlic inhibited platelet aggregation and the release reaction. Subsequent experiments designed characterize inhibitory component revealed that activity was i) associated with small molecular-weight components, ii) possessed typical odor contained an abundance sulfur, iii) could be extracted organic solvents, iv) temperatures above 56° C alkaline pH 8.5 quickly destroyed activity. The Rf value major after thin-layer chromatographic separation similar allicin, unique thiosulfinate in previously shown possess strong antibiotic antifungal properties. Allicin synthesized. On plates, allicin co-migrated garlic. At 10 uM concentration, completely Comparative studies suggest inhibitor may allicin.