Mechanisms of mRNA surveillance in eukaryotes.

摘要: ▪ Abstract A conserved mRNA degradation system, referred to as surveillance, exists in eukaryotic cells degrade aberrant mRNAs. A defining aspect of transcripts is that the spatial relationship between termination codon and specific downstream sequence information has been altered. key, yet unknown, feature surveillance system how this assessed individual transcripts. Two views have emerged describe discrimination proper improper might occur. In first view, a complex assembles onto after translation termination, scans 3′ 5′ direction for limited distance. If encountered during scanning, then targets transcript rapid decay. An alternate view suggests influences occurs. This encompasses several ideas including: ...