Cholinergic and glutamatergic activation reverses working memory failure by hippocampal histamine H1 receptor blockade in rats.

摘要: Intrahippocampal administration of the histamine H1 receptor antagonist pyrilamine (3.2-32 ug/ side) but not H2 cimetidine (1.0-10 microg/side) increased number errors in working memory task with a three-panel runway setup. The increase induced by intrahippocampal 32 microg/side was significantly reduced concurrent infusion agonist 2-pyridylethylamine (3.2 and 10 microg/side). cholinesterase inhibitor physostigmine ( 1.0 3.2 D-cycloserine (0.32 microg/side), partial at glycine binding site on NMDA receptor/channel complex, pyrilamine. These results suggest that hippocampal histaminergic activity via is necessary for normal processes septohippocampal cholinergic activation positive modulation through can alleviate dysfunction receptor-mediated neurotransmission involved function.