Effects of histamine H1 receptor antagonists on hippocampal theta rhythm during spatial memory performance in rats

摘要: Abstract The effects of histamine H 1 receptor antagonists (promethazine, diphenhydramine, chlorphenilamine and triprolidine) on hippocampal theta rhythm during eight-arm radial maze performance were investigated using rats. Promethazine showed a significant increase in the number total errors working memory at doses 10 20 mg/kg, was also observed reference dose 20 mg/kg. Diphenhydramine 20 mg/kg triprolidine 35 mg/kg caused increases total, errors. Promethazine, diphenhydramine chlorphenilamine, having potent anti-muscarinic properties, increased power On other hand, triprolidine, which has weak properties compared with antagonists, decreased 35 mg/kg. These results suggest that rather than anti-histamine may affect spatial deficit induced by promethazine, chlorphenilamine.