The influence of peripheral arterial disease on outcomes: a pooled analysis of mortality in eight large randomized percutaneous coronary intervention trials.

摘要: OBJECTIVES We aimed to evaluate clinical outcomes among peripheral arterial disease (PAD) patients following percutaneous coronary intervention (PCI). BACKGROUND A significant proportion of with artery undergoing PCI have concomitant PAD, which may be associated worse outcomes. METHODS performed a pooled analysis 8 randomized trials. included multicenter trials that compared antiplatelet therapies (EPIC, EPILOG, EPISTENT, RAPPORT, CAPTURE, IMPACT-II, TARGET, and CREDO) had baseline PAD status recorded. Multivariable analyses were stepwise logistic regression for 7- 30-day Cox 6-month 1-year events. RESULTS In our 19,867 PCI, 1,602 (8.1%) previously diagnosed PAD. Patients higher incidences 7-day death (1.0% vs. 0.4%; p < 0.001) or myocardial infarction (MI) (6.8% 5.6%; = 0.047), (1.7% 0.7%; MI (7.4% 6.1%; 0.05), (4.2% 1.5%; (9.1%, 7.7%; 0.048), (5.0% 2.1%; 0.001). There was trend toward major bleeding risk (4.8% 3.9%; 0.06). With multivariable analyses, remains predictor mortality at 30 days (hazard ratio [HR] 1.67, 95% confidence interval [CI] 1.03 2.70; 0.039), 6 months (HR 1.76, CI 1.31 2.37; 0.001), 1 year 1.46, 1.08 1.96; 0.013). CONCLUSIONS The presence is rates post-PCI MI, an independent short- long-term mortality.