Long-Term Prognostic Risk in Lower Extremity Peripheral Arterial Disease as a Function of the Number of Peripheral Arterial Lesions.

摘要: Background Although patients with peripheral artery disease (PAD) are known to have an increased risk of adverse prognosis, simple techniques further risk‐stratify PAD would be clinically useful. A plausible but unexplored factor predict such greater burden, manifested as multiple lower extremity lesions. The aim this study was examine the association between having versus isolated lesions and long‐term prognosis. Methods Results prospective cohort 756 newly diagnosed underwent duplex ultrasound testing determine number Cox regression models examined independent lesion (≥3 2 1) prognosis (defined a composite end point comprising first occurrence either amputation, admission for heart failure, nonfatal stroke, myocardial infarction, or unstable angina mortality), adjusting demographic clinical factors. Analyses were replicated using advanced Cox‐based model events. total 173 (23%) had ≥3 lesions, 197 (26%) 386 (51%) 1 lesion. After median follow‐up 3.2 years, experiencing event (adjusted hazard ratio 1.60, 95% CI 1.08–2.38, P =0.020) events 1.53, 1.08–2.18, =0.018). Patients similar those Conclusions Among patients, is associated over 3 years follow‐up. Assessing might serve risk‐stratification tool at initial diagnosis.