Hypothermia induced by the putative 5-HT1A agonists LY165163 and 8-OH-DPAT is not prevented by 5-HT depletion.
作者： P.H. Hutson , T.P. Donohoe , G. Curzon
DOI: 10.1016/0014-2999(87)90536-X
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摘要: The putative 5-HT1A agonist 1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl)piperazine (LY165163, PAPP) (1, 2, 4, 10 mg/kg s.c.) caused a significant and dose-dependent hypothermia in rats, 30 60 min after injection. decreases of temperature were less marked than that by 8-OH-DPAT 1 s.c.). Depletion brain serotonin (5-HT) 91% following pretreatment with p-chlorophenylalanine (pCPA) (150 i.p. on three successive days) significantly enhanced the hypothermic effects both (0.25 LY165163 (4 LY165163-induced was also somewhat depletion hypothalamic 5-HT 76% infusion 5,7-dihydroxytryptamine (5,7-DHT) micrograms) into third ventricle. Results indicate induced agonists rat is not dependent presynaptic stores therefore probably mediated postsynaptic receptors.
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