TLR9 is expressed in human papillomavirus-positive cervical cells and is overexpressed in persistent infections

摘要: Control of human papillomavirus (HPV) infection involves the activation Toll-like receptors (TLRs), key components mucosal antiviral response. Available studies on TLR expression in HPV-positive cervical cells are limited and reported conflicting results. This study quantified 2, 3, 4, 7 9 transcripts low-risk (LR) high-risk (HR) HPV-negative samples from 154 women attending a gynaecological clinic. Expression levels 4 did not differ among samples, whereas TLR9 were quite significantly higher LR marginally significant HR with respect to samples. Interestingly, subgroup documented previous HPV-infection, extremely patients persistently positive same HPV genotype for more than 1 year, who cleared those re-infected different genotype. These findings implicate response HPVs, including 16 known interfere transcription cell lines. Elevated without clearance infected could drive inflammation thereby contributing cancer risk.