Functionalized thermoresponsive microgels based on N-isopropylacrylamide: Energetics and mechanism of phase transitions
作者： Valerij Y. Grinberg , Tatiana V. Burova , Natalia V. Grinberg , Anastasiya G. Buyanovskaya , Alexei R. Khokhlov
DOI: 10.1016/J.EURPOLYMJ.2020.109722
关键词:
摘要: Abstract Nano- and micro-sized stimuli-responsive polymer containers capable of an effective controlled binding release ionic amphiphilic drugs are highly demanded in drug delivery. Thermoresponsive cross-linked microgels based on N-isopropylacrylamide (NIPAM) were synthesized by precipitation polymerization aqueous media. The functionalized the introduction component (acrylic acid, AA, or vinyl sulfonate, VSA) either as a comonomer (NIPAM-co-AA NIPAM-co-VSA microgels) interpenetrating network (PNIPAM-PAA microgel). thermoresponsive behavior was investigated high-sensitivity differential scanning calorimetry. Thermodynamic parameters phase transitions (the transition temperature, enthalpy, width) for copolymer determined. involving weak strong ionogenic groups differ drastically energetics. This implies different types their primary structures provided affinity segregation reaction mixture under conditions. microgel functionalization via networks does not affect notably temperature typical reference parent PNIPAM but reduces cooperativity. An analysis heat capacity profile reveals some features mechanism thermoresponsivity microgels.
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