[The essential fatty acids omega-6 and omega-3: from their discovery to their use in therapy].

作者: Caramia G

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摘要: In 1929 Burr and discovered the essential fatty acids omega-6 omega-3. Since then, researchers have shown a growing interest in unsaturated as they form framework for organism's cell membranes, particularly neurones brain, are involved energy-transformation process, regulate information flows between cells. Polyunsaturated also precursors of ''hormonal'' molecules, often with opposing effects, prostaglandins, prostacyclins, thromboxanes, leukotrienes, lipossines, resolvines, protectines that immunity, platelet aggregation, inflammation, etc. They showed raised levels polyunsaturated omega-3 tissue correlate reduced incidence degenerative cardiovascular disease, some mental illnesses such depression, neuro-degenerative diseases Alzheimer's. The balance allows membranes to develop exactly right flexibility fluidity, carry messages neurones, is determining factor physical well-being has profound influence on all body's inflammatory responses. results number scientific studies suggest contribute measuring restricting symptoms, whereas (and saturated fats) give free range responses amplify allergic reactions. Today Western countries, ratio diet weighted 1:10 favour up 1:25 areas, while proper functioning 4:1 generally considered optimum. addition, type followed countries very rich fats like butter animal fats, but because an excessive supply these less noble lose this can affect way work. An appropriate supplement be efficient, effective necessary meet needs, enhance its daily functions promote health longevity.

参考文章(94)
Malavolta M, Frega Ng, Cocchi M, Mozzon M, Gagliardini R, Caramia G, Fatty acids composition of plasma phospholipids and triglycerides in children with cystic fibrosis. The effect of dietary supplementation with an olive and soybean oils mixture. La Pediatria medica e chirurgica : Medical and surgical pediatrics. ,vol. 25, pp. 42- ,(2003)
L Gagliardi, G A D Miggiano, [Diet, nutrition and rheumatoid arthritis]. Clinica Terapeutica. ,vol. 156, pp. 115- 123 ,(2005)
Sheila M. Innis, POLYUNSATURATED FATTY ACIDS IN HUMAN MILK An Essential Role in Infant Development Advances in Experimental Medicine and Biology. ,vol. 554, pp. 27- 43 ,(2004) , 10.1007/978-1-4757-4242-8_5
Maggie B. Covington, Omega-3 fatty acids. American Family Physician. ,vol. 70, pp. 133- 140 ,(2004)
Toby Lawrence, Magali Bebien, George Y. Liu, Victor Nizet, Michael Karin, IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation Nature. ,vol. 434, pp. 1138- 1143 ,(2005) , 10.1038/NATURE03491
Catherine Godson, Siobhan Mitchell, Killeen Harvey, Nicos A. Petasis, Nancy Hogg, Hugh R. Brady, Cutting Edge: Lipoxins Rapidly Stimulate Nonphlogistic Phagocytosis of Apoptotic Neutrophils by Monocyte-Derived Macrophages The Journal of Immunology. ,vol. 164, pp. 1663- 1667 ,(2000) , 10.4049/JIMMUNOL.164.4.1663
Makoto Arita, Taisuke Ohira, Yee-Ping Sun, Siva Elangovan, Nan Chiang, Charles N. Serhan, Resolvin E1 Selectively Interacts with Leukotriene B4 Receptor BLT1 and ChemR23 to Regulate Inflammation Journal of Immunology. ,vol. 178, pp. 3912- 3917 ,(2007) , 10.4049/JIMMUNOL.178.6.3912
George O. Burr, Mildred M. Burr, A NEW DEFICIENCY DISEASE PRODUCED BY THE RIGID EXCLUSION OF FAT FROM THE DIET Journal of Biological Chemistry. ,vol. 82, pp. 345- 367 ,(1929) , 10.1016/S0021-9258(20)78281-5
C. H. Kellaway, E. R. Trethewie, THE LIBERATION OF A SLOW-REACTING SMOOTH MUSCLE-STIMULATING SUBSTANCE IN ANAPHYLAXIS Quarterly Journal of Experimental Physiology and Cognate Medical Sciences. ,vol. 30, pp. 121- 145 ,(1940) , 10.1113/EXPPHYSIOL.1940.SP000825