Neuropeptide Y: a new mediator linking sympathetic nerves, blood vessels and immune system?
作者： Zofia Zukowska , Jennifer Pons , Edward W Lee , Lijun Li
DOI: 10.1139/Y03-006
关键词:
摘要: Neuropeptide Y (NPY136), a sympathetic cotransmitter and neurohormone, has pleiotropic activities ranging from the control of obesity to anxiolysis cardiovascular function. Its actions are mediated by multiple Gi/o-coupled receptors (Y1Y5) modulated dipeptidyl peptidase IV (DPPIV/cd26), which inactivates NPY's Y1-agonistic activity but generates Y2 Y5-agonist, NPY336. Released activity, NPY is major mediator stress, responsible for prolonged vasoconstriction via Y1 receptors. also mediate potent vascular growth-promoting leading in vivo rodents neointima formation. This association polymorphism signal peptide with increased lipidemia carotid artery thickening humans strongly suggest role atherosclerosis. DPPIV/cd26 coexpressed endothelium, where activates angiogenesis. A similar system exists immune cells, coactivated in...
nrcresearchpress.com参考文章(69)
Lars Grundemar, Sören P. Sheikh, Claes Wahlestedt, Characterization of Receptor Types for Neuropeptide Y and Related Peptides The Biology of Neuropeptide Y and Related Peptides. pp. 197- 239 ,(1993) , 10.1007/978-1-59259-465-8_5
P Kogner, A Ericsson, G Barbany, H Persson, E Theodorsson, O Bjork, Neuropeptide Y (NPY) synthesis in lymphoblasts and increased plasma NPY in pediatric B-cell precursor leukemia. Blood. ,vol. 80, pp. 1324- 1329 ,(1992) , 10.1182/BLOOD.V80.5.1324.1324
Zofia Zukowska-Grojec, Claes Wahlestedt, Origin and Actions of Neuropeptide Y in the Cardiovascular System The Biology of Neuropeptide Y and Related Peptides. pp. 315- 388 ,(1993) , 10.1007/978-1-59259-465-8_8
Serenay Elgün, Aytaç Keskinege, Hakan Kumbasar, Dipeptidyl peptidase IV and adenosine deaminase activity: Decrease in depression Psychoneuroendocrinology. ,vol. 24, pp. 823- 832 ,(1999) , 10.1016/S0306-4530(99)00039-6
Michael Irwin, Marvin Brown, Thomas Patterson, Richard Hauger, Anne Mascovich, Igor Grant, None, Neuropeptide Y and natural killer cell activity: findings in depression and Alzheimer caregiver stress The FASEB Journal. ,vol. 5, pp. 3100- 3107 ,(1991) , 10.1096/FASEBJ.5.15.1743441
K Sakaguchi, L Takács, D Doyle, E Appella, L A Bristol, Thymocyte costimulating antigen is CD26 (dipeptidyl-peptidase IV). Costimulation of granulocyte, macrophage, and T lineage cell proliferation via CD26. Journal of Immunology. ,vol. 149, pp. 367- 372 ,(1992)
Annette Beck-Sickinger, Remi Quirion, Dan Larhammar, Henri N. Doods, Herbert Herzog, Thue Schwartz, Helen Cox, Thomas Westfall, Martin C. Michel, XVI. International Union of Pharmacology Recommendations for the Nomenclature of Neuropeptide Y, Peptide YY, and Pancreatic Polypeptide Receptors Pharmacological Reviews. ,vol. 50, pp. 143- 150 ,(1998)
M. De la Fuente, S. Medina, M. Del Rio, M.D. Ferrández, A. Hernanz, Effect of aging on the modulation of macrophage functions by neuropeptides. Life Sciences. ,vol. 67, pp. 2125- 2135 ,(2000) , 10.1016/S0024-3205(00)00799-2
Dominique Schols, Paul Proost, Sofie Struyf, Anja Wuyts, Ingrid De Meester, Simon Scharpé, Jo Van Damme, Erik De Clercq, CD26-processed RANTES(3–68), but not intact RANTES, has potent anti-HIV-1 activity Antiviral Research. ,vol. 39, pp. 175- 187 ,(1998) , 10.1016/S0166-3542(98)00039-4
Adam K. Myers, Armida P. Torres Duarte, Zofia Zukowska-Grojec, Immunoreactive neuropeptide Y (NPY) in plasma and platelets of rat and mouse strains and human volunteers Regulatory Peptides. ,vol. 47, pp. 239- 245 ,(1993) , 10.1016/0167-0115(93)90391-K