Spectral-Domain Optical Coherence Tomography Features of Acute Syphilitic Posterior Placoid Chorioretinitis: The Role of Autoimmune Response in Pathogenesis

摘要: Purpose: Syphilis is an infectious disease that can cause a wide variety of ocular signs. One the rarest manifestations syphilis acute syphilitic posterior placoid chorioretinitis (ASPPC). We report on spectral-domain optical coherence tomography (SD-OCT) features case diagnosed with unilateral ASPPC. Methods: A 64-year-old man presented sudden loss visual acuity (VA) in right eye. His only clinical sign was large, geographic, yellow-white lesion centered fovea. Our patient studied SD-OCT presentation and during follow-up, as well fluorescein indocyanine green angiography, electrophysiological study, serologic autoimmune screening. Results: Laboratory workup revealed positive serology for active elevated anti-beta2 glycoprotein I antibodies. showed marked distortion both choroidal outer retinal architecture. After treatment, best-corrected VA improved to 20/25. Pattern electroretinography displayed severe reduction P50 amplitude, which late follow-up. Six months after presentation, 20/25 antibodies returned normal levels. Conclusions: findings are compatible immunologically mediated temporary physiological impairment neuroretina, since changes seen by could not have normalized if they were due anatomical injury. The results our study provide clues understanding pathogenesis this allow us define characteristic temporal sequence events