Association of Body Composition and Hormonal and Inflammatory Factors With Tibial Cartilage Volume and Sex Difference in Cartilage Volume in Young Adults
作者： Benny Antony , Alison Venn , Flavia Cicuttini , Lyn March , Leigh Blizzard
DOI: 10.1002/ACR.22715
关键词:
摘要: Objective To describe the associations between body composition, hormonal and inflammatory factors measured 5 years prior tibial cartilage volume in young adults to explore if these contribute sex difference volume. Methods: Subjects broadly representative of adult Australian population (n = 328, aged 31-41 years, female 47.3%) were selected. They underwent T1-weighted fat-suppressed magnetic resonance imaging (MRI) their knees. Tibial was from MRI. Sex hormone binding globulin (SHGB) testosterone a subset females C-reactive protein (CRP) fibrinogen both sexes prior. Body mass index (BMI), fat lean calculated height, weight skinfolds. Results: In multivariable analyses, correlates included (β = 26.4 mm3; 95% confidence interval [95% CI] 13.6, 39.1), (β = −11.8 mm3; CI −22.2, −1.4), (β = − 146.4 mm3; CI −276.4, −16.4), but not BMI, testosterone, or CRP level. In women, SHBG positively associated with (β = 0.67 mm3; 0.14, 1.20) Free Androgen Index negatively lateral (β = −0.04 mm3; −0.07, 0.00). Men had 13% more (500 mm3) than women. The magnitude this association decreased by 38%, 20%, 37% after adjustment for mass, fibrinogen, respectively. Conclusion: Body hormones correlate knee life. is contributed largely variations composition and/or fibrinogen.
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