Benefits of massive weight loss on symptoms, systemic inflammation and cartilage turnover in obese patients with knee osteoarthritis
作者： P. Richette , C. Poitou , P. Garnero , E. Vicaut , J.-L. Bouillot
关键词:
摘要: Objective To investigate the effect of massive weight loss on (1) knee pain and disability, (2) low-grade inflammation metabolic status (3) joint biomarkers in obese patients with osteoarthritis (OA). Methods 140 involved a gastric surgery programme were screened for painful OA, 44 included (age ± 10.3 years, body mass index (BMI) 50.7 7.2 kg/m 2 ). Clinical data biological samples collected before 6 months after surgery. Results Before surgery, interleukin (IL-6) levels correlated high-sensitivity C reactive protein (hsCRP) (p=0.006) Helix-II (p=0.01), biomarker cartilage turnover, Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) function score (p=0.03). Surgery resulted substantial decrease BMI (−20%). Levels insulin resistance decreased at months. Knee (24.5 21 mm vs 50 26.6 mm; p Conclusion Massive improves decreases inflammation. Change suggests structural cartilage.
sci-hub.se 参考文章(49)
R Ogawa, T Toda, T Morimoto, Y Toda, T Wada, S Takemura, Change in body fat, but not body weight or metabolic correlates of obesity, is related to symptomatic relief of obese patients with knee osteoarthritis after a weight control program. The Journal of Rheumatology. ,vol. 25, pp. 2181- 2186 ,(1998)
Paolo Giannoni, Mark Siegrist, Ernst B Hunziker, Marcy Wong, None, The mechanosensitivity of cartilage oligomeric matrix protein (COMP) Biorheology. ,vol. 40, pp. 101- 109 ,(2003)
Susan Tseng, A. Hari Reddi, Paul E. Di Cesare, Cartilage Oligomeric Matrix Protein (COMP): A Biomarker of Arthritis Biomarker Insights. ,vol. 4, pp. 33- 44 ,(2009) , 10.4137/BMI.S645
Timothy M. Griffin, Farshid Guilak, Why is obesity associated with osteoarthritis? Insights from mouse models of obesity. Biorheology. ,vol. 45, pp. 387- 398 ,(2008) , 10.3233/BIR-2008-0485
Seong-Su Nah, In-Young Choi, Bin Yoo, Yong Gil Kim, Hee-Bom Moon, Chang-Keun Lee, Advanced glycation end products increases matrix metalloproteinase-1, -3, and -13, and TNF-α in human osteoarthritic chondrocytes FEBS Letters. ,vol. 581, pp. 1928- 1932 ,(2007) , 10.1016/J.FEBSLET.2007.03.090
Stephen P. Messier, Richard F. Loeser, Michelle N. Mitchell, Gianfranco Valle, Timothy P. Morgan, W. Jack Rejeski, Walter H. Ettinger, Exercise and weight loss in obese older adults with knee osteoarthritis: a preliminary study. Journal of the American Geriatrics Society. ,vol. 48, pp. 1062- 1072 ,(2000) , 10.1111/J.1532-5415.2000.TB04781.X
Marjan M. C. Steenvoorden, Tom W. J. Huizinga, Nicole Verzijl, Ruud A. Bank, H. Karel Ronday, Hilco A. F. Luning, Floris P. J. G. Lafeber, René E. M. Toes, Jeroen DeGroot, Activation of receptor for advanced glycation end products in osteoarthritis leads to increased stimulation of chondrocytes and synoviocytes. Arthritis & Rheumatism. ,vol. 54, pp. 253- 263 ,(2006) , 10.1002/ART.21523
Marjolaine Gosset, Francis Berenbaum, Colette Salvat, Alain Sautet, Audrey Pigenet, Khadija Tahiri, Claire Jacques, Crucial role of visfatin/pre–B cell colony‐enhancing factor in matrix degradation and prostaglandin E2 synthesis in chondrocytes: Possible influence on osteoarthritis Arthritis & Rheumatism. ,vol. 58, pp. 1399- 1409 ,(2008) , 10.1002/ART.23431
Linda J. Sandell, Obesity and osteoarthritis: Is leptin the link? Arthritis & Rheumatism. ,vol. 60, pp. 2858- 2860 ,(2009) , 10.1002/ART.24862
Katherine A. Elder, Bruce M. Wolfe, Bariatric surgery: a review of procedures and outcomes. Gastroenterology. ,vol. 132, pp. 2253- 2271 ,(2007) , 10.1053/J.GASTRO.2007.03.057