Interleukin-1 Abrogate sLong-Term Depressio no fHippocampa lCA1 Synapti cTransmission

作者： Isabell Edelcroix , Nori Omatsuki

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摘要: KE YWORDS interleukin ;cytokine ;lymphocyte ;hippocampu ssynapti cplasticity; long-ter mpotentiation ;knockou tmouse ABSTRACT Althoug hinterleukin-1 (IL-1 )i swel lknow nt omodulat esynaptic transmissio nan dplasticit yo fth ehippocampus ,n ostud yha sye tevaluate dho wthis cytokin eaffect slong-ter mdepressio n(LTD) ,on eo emajo rform so fhippocampal synapti cplasticity .Her ew erepor ttha ta tSchaffe rcollateral-CA 1synapses ,bath applicatio no fIL-1 induce sa long-lastin gdecreas ei nsynapti cstrengt hi nintac tslices, bu tno ti ndisinhibite dslice si nth epresenc fbicuculline , a-aminobutyri cacid recepto rantagonist .Th eIL-1-induce dsynapti cdepressio nefficientl yforeclose dthe subsequen tinductio fLT Di nrespons et oa 1-H ztetanu sand ,conversely ,i twa salso prevente db ypreexistin gLTD .Thes eresult ssugges tIL-1-induced ,persistent depressio fsynapti cefficac yi srequire dfo rGABAergi cactivatio dshares ,a tleast i npart commo ncellula rmechanis mfo rLTD .Synaps e47:5 4-57 ,2003. ©200 2Wiley-Liss ,Inc.

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Interleukin-1 Abrogate sLong-Term Depressio no fHippocampa lCA1 Synapti cTransmission

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Interleukin-1 Abrogate sLong-Term Depressio no fHippocampa lCA1 Synapti cTransmission

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