The Inhibitory Effect of Interleukin-1β on Long-Term Potentiation Is Coupled with Increased Activity of Stress-Activated Protein Kinases

摘要: Long-term potentiation (LTP) in perforant path-granule cell synapses is decreased aged rats, stressed and rats injected intracerebroventricularly with the proinflammatory cytokine interleukin-1β (IL-1β). One factor that common to these experimental conditions an increase concentration of IL-1β dentate gyrus, suggesting a causal relationship between compromise LTP increased concentration. In this study, we have investigated downstream consequences report reduced was accompanied by decrease KCl-stimulated glutamate release synaptosomes prepared from although unstimulated increased. These changes were paralleled activity stress-activated kinases, c-Jun N-terminal kinase (JNK) p38 mitogen-activated protein kinase. Intracerebroventricular injection reactive oxygen species production hippocampal tissue, whereas H2O2 activities both JNK vitro. Dietary manipulation antioxidant vitamins E C blocked production, stimulation activity, attenuation release, IL-1β-induced inhibitory LTP. We propose stimulates which turn may inhibit result compromised actions are consequence species.