Mutagenicity and teratogenicity studies of vitacoxib in rats and mice.

作者: Jianzhong Wang , Feifei Sun , Shusheng Tang , Suxia Zhang , Jing Li

DOI: 10.1016/J.TOXREP.2018.08.007

关键词:

摘要: Abstract Vitacoxib is a new drug candidate for treatment of inflammation, pain and fever as selective cyclooxygenase-2 inhibitors. In the current study, mice sperm abnormality, mammalian erythrocyte micronucleus in vivo chromosome aberration, teratogenicity SD rats were evaluated. did not cause an increase frequency structural aberrations, nor it produce number micro nucleated polychromatic erythrocytes at dose 1250–5000 mg/kg body weight (BW). There no toxicological signs observed test female 200–5000 mg/kg BW. Based on these results studies, vitacoxib does appear to be mutagenicity teratogenicity.

参考文章(8)
Jianzhong Wang, Feifei Sun, Shusheng Tang, Suxia Zhang, Xingyuan Cao, Acute, mutagenicity, teratogenicity and subchronic oral toxicity studies of diaveridine in rodents Environmental Toxicology and Pharmacology. ,vol. 40, pp. 660- 670 ,(2015) , 10.1016/J.ETAP.2015.08.022
K D Rainsford, Introduction — The coxib controversies Inflammopharmacology. ,vol. 13, pp. 331- 341 ,(2005) , 10.1163/156856005774415628
Markus Frentz, Miriam Goss, Martin Reim, Norbert F. Schrage, Repeated exposure to benzalkonium chloride in the Ex Vivo Eye Irritation Test (EVEIT): observation of isolated corneal damage and healing. Atla-alternatives To Laboratory Animals. ,vol. 36, pp. 25- 32 ,(2008) , 10.1177/026119290803600105
Jeremy M. Fitzpatrick, David W. Roberts, Grace Patlewicz, Is skin penetration a determining factor in skin sensitization potential and potency? Refuting the notion of a LogKow threshold for skin sensitization. Journal of Applied Toxicology. ,vol. 37, pp. 117- 127 ,(2017) , 10.1002/JAT.3354
Fernando Bessone, Nelia Hernandez, Marcelo Gabriel Roma, Ezequiel Ridruejo, Manuel Mendizabal, Inmaculada Medina-Cáliz, Mercedes Robles-Díaz, M Isabel Lucena, Raúl J Andrade, None, Hepatotoxicity induced by coxibs: how concerned should we be? Expert Opinion on Drug Safety. ,vol. 15, pp. 1463- 1475 ,(2016) , 10.1080/14740338.2016.1225719
Jianzhong Wang, Feifei Sun, Shusheng Tang, Suxia Zhang, Pengyue Lv, Jing Li, Xingyuan Cao, Safety assessment of vitacoxib: Acute and 90-day sub-chronic oral toxicity studies Regulatory Toxicology and Pharmacology. ,vol. 86, pp. 49- 58 ,(2017) , 10.1016/J.YRTPH.2017.02.020
Jianzhong Wang, Zhiyuan Li, Feifei Sun, Shusheng Tang, Suxia Zhang, Pengyyue Lv, Jing Li, Xingyuan Cao, Evaluation of dermal irritation and skin sensitization due to vitacoxib. Toxicology reports. ,vol. 4, pp. 287- 290 ,(2017) , 10.1016/J.TOXREP.2017.06.003
Jianzhong Wang, Tingting Zhao, Shusheng Tang, Suxia Zhang, Pengyyue Lv, Jing Li, Xingyuan Cao, Safety assessment of vitacoxib: 180-day chronic oral toxicity studies. Regulatory Toxicology and Pharmacology. ,vol. 95, pp. 244- 249 ,(2018) , 10.1016/J.YRTPH.2018.03.024