作者: Jianzhong Wang , Feifei Sun , Shusheng Tang , Suxia Zhang , Jing Li
DOI: 10.1016/J.TOXREP.2018.08.007
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摘要: Abstract Vitacoxib is a new drug candidate for treatment of inflammation, pain and fever as selective cyclooxygenase-2 inhibitors. In the current study, mice sperm abnormality, mammalian erythrocyte micronucleus in vivo chromosome aberration, teratogenicity SD rats were evaluated. did not cause an increase frequency structural aberrations, nor it produce number micro nucleated polychromatic erythrocytes at dose 1250–5000 mg/kg body weight (BW). There no toxicological signs observed test female 200–5000 mg/kg BW. Based on these results studies, vitacoxib does appear to be mutagenicity teratogenicity.