Hepatotoxicity induced by coxibs: how concerned should we be?
作者： Fernando Bessone , Nelia Hernandez , Marcelo Gabriel Roma , Ezequiel Ridruejo , Manuel Mendizabal
DOI: 10.1080/14740338.2016.1225719
关键词:
摘要: ABSTRACTIntroduction: The selective inhibitors of COX-2, coxibs, are nonsteroidal anti-inflammatory drugs (NSAIDs) that have much better gastrointestinal safety profile as compared with non-selective NSAIDs. In this review, we analyze both the epidemiological features coxib-induced hepatotoxicity and clinical impact coxib-associated liver damage, based on literature data.Areas covered: We carried out a search databases MEDLINE (PubMed), LILACS SCIELO, from December 1999 to January 2016, retrieve studies exploring real coxibs in toxicity COX-2 inhibitor NSAIDs.Expert opinion: Although reliable data incidence celecoxib- etoricoxib-induced lacking, because cohort been generally underpowered detect hepatic events, scarcely related hepatotoxicity. Hence, injury seems be an uncommon event, yet exhibits wide spectrum damage. Increasing ...
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