Prolonged cholestasis associated with short-term use of celecoxib

摘要: Summary Drug-induced liver injury due to celecoxib, a first generation Cox-2 inhibitor, has been rarely reported. We describe one case of severe and prolonged cholestasis after treatment with celecoxib for 12 days in young woman no evidence other causes disease or allergy. Jaundice lasted 3 months, pruritus abnormal biochemistries persisted 18 months stopping the drug. Liver biopsy specimens showed cholestatic pattern only minimal mononuclear infiltrate portal tracts. This report supports notion that may cause bland, long term cholestasis.