Hemoglobin-Based Blood Substitutes and Enhanced Susceptibility to Bacterial Infections
作者： John R. Mahoney , John W. Eaton
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摘要: Abstract : Chemically modified human hemoglobin is currently being studied as a potential blood substitute for use in military and emergency medical applications. We have tested one form of hemoglobin, DBBF-HB, against normal Hb order to determine its ability promote hemoglobin-driven bacterial infections. Using an experimental model E. coli peritonitis we determined that DBBF-HB equally likely unmodified (on mole basis) lead fatal outcome this model. Further investigations were undertaken elucidate the molecular mechanism these The strains exhibit hemoglobin- adjuvant effect are resistant phagocytosis by peritoneal macrophages. This feature may explain why necessary (nutritional iron) but not sufficient promotion examining composition outer membrane proteins hemoglobin-adjuvant strains. In addition, using biological approach, attempting clone gene(s) responsible phenotype coli. understanding driven infections enable rational design safe substitute. Bacterial infections, Blood substitutes, Hemoglobin-based substitutes.
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