Seropositivity for HIV and the development of AIDS or AIDS related condition: three year follow up of the San Francisco General Hospital cohort.
作者： A. R Moss , P. Bacchetti , D. Osmond , W. Krampf , R. E Chaisson
关键词:
摘要: The three year actuarial progression rate to the acquired immune deficiency syndrome (AIDS) in a cohort of men San Francisco who were seropositive for human immuno-deficiency virus (HIV) was 22%. An additional 26 (19%) developed AIDS related conditions. β 2 Microglobulin concentration, packed cell volume, HIV p24 antigenaemia, and proportion number T4 lymphocytes each independently predicted AIDS. most powerful predictor. 111 subjects tested normal by all predictors (40%) had 7%, 68 abnormal two or more (24%) 57%. Two thirds progressed last group. median lymphocyte count did not progress fell from 626 × 10 6 327 /1. antigenaemia 7% per year. predictive variables rose 41%. At years an estimated showed clinical AIDS, condition, laboratory results that highly It is concluded observed rates distribution at half will develop six after start study, quarters condition.
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sci-hub.se 参考文章(13)
Weintraub M, Green J, Gottleib J, Muggia F, Hymes K, Ragaz A, Friedman-Kien A, Demopoulos R, Marmor M, Laubenstein L, Kaposis sarcoma and Pneumocystis pneumonia among homosexual men--New York City and California. Morbidity and Mortality Weekly Report. ,vol. 30, ,(1981)
I Berggård, A G Bearn, Isolation and Properties of a Low Molecular Weight β2-Globulin Occurring in Human Biological Fluids Journal of Biological Chemistry. ,vol. 243, pp. 4095- 4103 ,(1968) , 10.1016/S0021-9258(18)93284-9
Robert R. Redfield, D. Craig Wright, Edmund C. Tramont, The Walter Reed Staging Classification for HTLV-III/LAV Infection New England Journal of Medicine. ,vol. 314, pp. 131- 132 ,(1986) , 10.1056/NEJM198601093140232
R. Gallo, S. Salahuddin, M Popovic, G. Shearer, M Kaplan, B. Haynes, T. Palker, R Redfield, J Oleske, B Safai, al. et, Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS Science. ,vol. 224, pp. 500- 503 ,(1984) , 10.1126/SCIENCE.6200936
Daniel P. Stites, Conrad H. Casavant, Thomas M. McHugh, Andrew R. Moss, Stuart L. Beal, John L. Ziegler, Alex M. Saunders, Noel L. Warner, Flow cytometric analysis of lymphocyte phenotypes in AIDS using monoclonal antibodies and simultaneous dual immunofluorescence Clinical Immunology and Immunopathology. ,vol. 38, pp. 161- 177 ,(1986) , 10.1016/0090-1229(86)90135-2
F Barre-Sinoussi, J. Chermann, F Rey, M. Nugeyre, S Chamaret, J Gruest, C Dauguet, C Axler-Blin, F Vezinet-Brun, C Rouzioux, W Rozenbaum, L Montagnier, Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science. ,vol. 220, pp. 868- 871 ,(1983) , 10.1126/SCIENCE.6189183
Susan Zolla-Pazner, Daniel William, Wafaa El-Sadr, Michael Marmor, Rosalyn Stahl, Quantitation of β2-Microglobulin and Other Immune Characteristics in a Prospective Study of Men at Risk for Acquired Immune Deficiency Syndrome JAMA: The Journal of the American Medical Association. ,vol. 251, pp. 2951- 2955 ,(1984) , 10.1001/JAMA.1984.03340460029020
M. ELAINE EYSTER, Natural History of Human Immunodeficiency Virus Infections in Hemophiliacs: Effects of T-Cell Subsets, Platelet Counts, and Age Annals of Internal Medicine. ,vol. 107, pp. 1- 6 ,(1987) , 10.7326/0003-4819-107-1-1
James J Goedert, Robert J Biggar, Stanley H Weiss, M Elaine Eyster, Mads Melbye, Susan Wilson, Harold M Ginzburg, Ronald J Grossman, Richard A DiGioia, William C Sanchez, Jose A Giron, Peter Ebbesen, Robert C Gallo, William A Blattner, Three-year incidence of AIDS in five cohorts of HTLV-III-infected risk group members. Science. ,vol. 231, pp. 992- 995 ,(1986) , 10.1126/SCIENCE.3003917
J ALLAIN, Serological markers in early stages of human immunodeficiency virus infection in haemophiliacs. The Lancet. ,vol. 328, pp. 1233- 1236 ,(1986) , 10.1016/S0140-6736(86)92673-5