Comparison of clinical manifestations of HIV infection among women by risk group, CD4+ cell count, and HIV-1 plasma viral load

摘要: OBJECTIVES: To compare the prevalence of HIV-related symptoms, physical examination findings, and hematologic variables among women whose risk for HIV is injection drug use since 1985 as opposed to sexual contact evaluate influence plasma viral load CD4+ cell count on clinical manifestations according risk. METHODS: Participants Epidemiology Research Study (HERS; a multicenter, prospective, controlled study infection in women) were administered behavior symptom interview, underwent examination, received testing, including counts done entry. Plasma HIV-1 loads performed stored frozen using an ultrasensitive branched-DNA (b-DNA) signal amplification assay. categorized or =500 cells/microl, characterized tertiles. RESULTS: Cross-sectional analysis was conducted data available 724 HIV-infected women: 387 had history intravenous 337 infected through heterosexual contact. The median 376 cells/microl; 1135 copies/ml; 281 (38.8%) undetectable load. In analyses adjusting level alone combined with level, users (IDUs) more likely than those report recent episode memory loss weight loss, but less have episodes genital herpes; enlarged livers body mass index (BMI) <24, hematocrit levels <34% platelet <150,000 cells/ml. After adjustment group, high medium associated presence oral hairy leukoplakia only highest histories fever thrush, leukoplakia, pseudomembranous candidiasis, BMI <24 <34%. CONCLUSIONS: this cohort women, distribution lower that previously reported populations men. This also shows some differences frequency signs, laboratory values between groups these results may be due effects rather infection. Signs symptoms identified increasing not different across suggest direct association findings