The effects of chronic binge alcohol on the genital microenvironment of simian immunodeficiency virus-infected female rhesus macaques.
作者： Nisha Loganantharaj , Whitney A. Nichols , Gregory J. Bagby , Julia Volaufova , Jason Dufour
关键词: Vagina 、 Transmission (medicine) 、 Disease 、 Immunology 、 Viral load 、 Gram staining 、 Alcohol abuse 、 Biology 、 Sex organ 、 Simian immunodeficiency virus
摘要: Abstract Alcohol abuse is a widespread problem among those at risk for and living with HIV can impact transmission disease progression. In this study we sought to use the simian immunodeficiency virus (SIV)-macaque model evaluate immunological virological changes in genital microenvironment of females exposed chronic alcohol. Female rhesus macaques were treated alcohol (n=6) or isocaloric sucrose 3 months then inoculated SIVmac251. To assess effects on SIV microenvironment, quantified plasma levels, measured inflammatory cells fluids, characterized microbial flora by gram stains over 10 weeks post-SIV infection. Following alcohol/sucrose treatment, significant differences observed vaginal alcohol-treated animals as compared controls. Microbial had decreased levels lactobacillus morphotypes i...
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