Nonneutropenic febrile episodes associated with docetaxel-based chemotherapy in patients with solid tumors

摘要: BACKGROUND Docetaxel is associated with severe lymphopenia and increased incidence of nonneutropenic infection. This study investigated the infections and/or febrile episodes in patients solid tumors receiving frontline docetaxel-based chemotherapy. METHODS Chemotherapy-naive treated chemotherapy were studied prospectively for development infections. RESULTS During a 2-year period, 680 cancer enrolled 24 protocols received 2867 cycles docetaxel-containing chemotherapy. Fifty-three (7.8%) developed episodes. The most common these pulmonary (n = 25), Pneumocystis carinii interstitial pneumonias 5), candidal =11), herpetic =4), cytomegaloviral =3) infections. Thirty-six (68%) had (< 900 cells per deciliter) 49 (92%) less than 400 CD4+ deciliter. Patients low cell count (≤ 200 significantly higher probability to develop opportunistic (P 0.002). was docetaxel/gemcitabine (18.3%; P 0.0001) docetaxel/CDDP (11.7%; 0.012) those docetaxel alone (3.6%). Conversely, 175 who 752 paclitaxel-containing regimens 410 2174 nontaxane-based 6 (3.4%; p=0.042) 12 (3%; p=0.001) infections, respectively. Less 10% two latter groups lymphopenic. risk infection 2.38 2.8 times paclitaxel chemotherapy, respectively. CONCLUSIONS Patients are at developing may be related, least partly, postchemotherapy lymphopenia. Cancer 2002;95:1326–33. © 2002 American Society. DOI 10.1002/cncr.10802