Protective Interfering Nucleic Acid Molecule and Virus-Like Particle, Viral Vector, or Virus Particle Containing the same as well as Pharmaceutical Composition Containing the Protective Interfering Nucleic Acid and its use
作者： Kupke Sascha , Reichl Udo , Frensing Timo , Zmora Pawel
DOI:
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摘要: In a first aspect, the present invention relates to an isolated nucleic acid molecule, in particular, RNA molecule containing particular substitutions. further composition comprising same as well virus-like particle, viral vector or virus particle according invention. The is suitable for use medicament treating infection. Further, pharmaceutical provided prophylactic vaccine Finally, vaccination against infection, influenza infection kit combination with wild type said protecting
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lens.org 参考文章(15)
Nigel Dimmock, Defective interfering virus ,(2007)
Danny L Wiedbrauk, Florence G Burleson, Thomas M Chambers, Virology: A Laboratory Manual ,(1992)
C A Smeenk, E G Brown, The influenza virus variant A/FM/1/47-MA possesses single amino acid replacements in the hemagglutinin, controlling virulence, and in the matrix protein, controlling virulence as well as growth. Journal of Virology. ,vol. 68, pp. 530- 534 ,(1994) , 10.1128/JVI.68.1.530-534.1994
Nigel Dimmock, Andrew Easton, Cloned Defective Interfering Influenza RNA and a Possible Pan-Specific Treatment of Respiratory Virus Diseases Viruses. ,vol. 7, pp. 3768- 3788 ,(2015) , 10.3390/V7072796
Fumitaka Momose, Yuji Kikuchi, Katsuhiro Komase, Yuko Morikawa, Visualization of microtubule-mediated transport of influenza viral progeny ribonucleoprotein. Microbes and Infection. ,vol. 9, pp. 1422- 1433 ,(2007) , 10.1016/J.MICINF.2007.07.007
E. Hoffmann, J. Stech, Y. Guan, R. G. Webster, D. R. Perez, Universal primer set for the full-length amplification of all influenza A viruses. Archives of Virology. ,vol. 146, pp. 2275- 2289 ,(2001) , 10.1007/S007050170002
Timo Frensing, None, Defective interfering viruses and their impact on vaccines and viral vectors. Biotechnology Journal. ,vol. 10, pp. 681- 689 ,(2015) , 10.1002/BIOT.201400429
Bernd Kalbfuss, Anne Knöchlein, Tina Kröber, Udo Reichl, Monitoring influenza virus content in vaccine production: precise assays for the quantitation of hemagglutination and neuraminidase activity. Biologicals. ,vol. 36, pp. 145- 161 ,(2008) , 10.1016/J.BIOLOGICALS.2007.10.002
ALICE S. HUANG, DAVID BALTIMORE, Defective Viral Particles and Viral Disease Processes Nature. ,vol. 226, pp. 325- 327 ,(1970) , 10.1038/226325A0
Eiryo Kawakami, Tokiko Watanabe, Ken Fujii, Hideo Goto, Shinji Watanabe, Takeshi Noda, Yoshihiro Kawaoka, Strand-specific real-time RT-PCR for distinguishing influenza vRNA, cRNA, and mRNA Journal of Virological Methods. ,vol. 173, pp. 1- 6 ,(2011) , 10.1016/J.JVIROMET.2010.12.014