Defective interfering virus
作者： Nigel Dimmock
DOI:
关键词: Virology 、 Biology 、 Interfering virus 、 Virus 、 Viral culture 、 Virulence 、 Embryonated 、 Microbiology 、 Influenza A virus 、 In vivo 、 Lethal dose
摘要: Cloned, i.e. defined, defective interfering (DI) influenza A virus is produced in embryonated hens eggs using a method which generates large quantities of DI material. Cloned then used tests on mice and ferrets given lethal challange wild-type virus. When cloned co-administered with dose virulent virus, are protected compared to control inactivated Mice survived the administration infective three weeks later still against Control received only no not therapeutic benefit administering found when takes place less than 48 hours after one subtype act vivo as an effective antiviral same or any other sub-type The effect has been have both prophylactic application infection humans, mammals birds.
lens.org 参考文章(11)
Ron A.M. Fouchier, Albert D.M.E. Osterhaus, Monique I.J. Spronken, Emmie De Wit, Defective influenza virus particles ,(2005)
Yoshihiro Kawaoka, Gabriele Neumann, Recombinant influenza viruses for vaccines and gene therapy ,(2000)
A. Mann, A.C. Marriott, S. Balasingam, R. Lambkin, J.S. Oxford, N.J. Dimmock, Interfering vaccine (defective interfering influenza A virus) protects ferrets from influenza, and allows them to develop solid immunity to reinfection Vaccine. ,vol. 24, pp. 4290- 4296 ,(2006) , 10.1016/J.VACCINE.2006.03.004
Lyndon J. Mitnaul, Mikhail N. Matrosovich, Maria R. Castrucci, Alexander B. Tuzikov, Nikolai V. Bovin, Darwyn Kobasa, Yoshihiro Kawaoka, BALANCED HEMAGGLUTININ AND NEURAMINIDASE ACTIVITIES ARE CRITICAL FOR EFFICIENT REPLICATION OF INFLUENZA A VIRUS Journal of Virology. ,vol. 74, pp. 6015- 6020 ,(2000) , 10.1128/JVI.74.13.6015-6020.2000
S. Noble, N.J. Dimmock, Characterization of Putative Defective Interfering (DI) A/WSN RNAs Isolated from the Lungs of Mice Protected from an Otherwise Lethal Respiratory Infection with Influenza Virus A/WSN (H1N1): A Subset of the Inoculum DI RNAs Virology. ,vol. 210, pp. 9- 19 ,(1995) , 10.1006/VIRO.1995.1312
Simon Noble, Lesley McLain, Nigel J Dimmock, Interfering vaccine: a novel antiviral that converts a potentially virulent infection into one that is subclinical and immunizing. Vaccine. ,vol. 22, pp. 3018- 3025 ,(2004) , 10.1016/J.VACCINE.2004.02.013
Susan Duhaut, Nigel J. Dimmock, Approximately 150 Nucleotides from the 5′ End of an Influenza A Segment 1 Defective Virion RNA Are Needed for Genome Stability during Passage of Defective Virus in Infected Cells Virology. ,vol. 275, pp. 278- 285 ,(2000) , 10.1006/VIRO.2000.0502
S Duhaut, Defective influenza A virus generated entirely from plasmids: its RNA is expressed in infected mouse lung and modulates disease Journal of Virological Methods. ,vol. 108, pp. 75- 82 ,(2003) , 10.1016/S0166-0934(02)00260-4
Philip A. Jennings, John T. Finch, Greg Winter, James S. Robertson, Does the higher order structure of the influenza virus ribonucleoprotein guide sequence rearrangements in influenza viral RNA? Cell. ,vol. 34, pp. 619- 627 ,(1983) , 10.1016/0092-8674(83)90394-X
Nigel J. Dimmock, Anthony C. Marriott, In vivo antiviral activity: defective interfering virus protects better against virulent Influenza A virus than avirulent virus. Journal of General Virology. ,vol. 87, pp. 1259- 1265 ,(2006) , 10.1099/VIR.0.81678-0