Fused imidazole derivatives as multidrug resistance modulators

摘要: This invention concerns the compounds of formula (I), N-oxide forms, pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein dotted line is an optional bond; n 1 or 2; R1 hydrogen; halo; formyl; C?1-4?alkyl optionally substituted with hydroxy, C1-4alkyloxy, C1-4alkylcarbonyloxy, imidazolyl, thiazolyl oxazolyl; a radical -X-COOR?5?, -X-CONR6R7 -X-COR10 -X- direct bond, C?1-4?alkanediyl C2-6alkenediyl; R?5? hydrogen, C?1-12?alkyl, Ar, Het, C1-6alkyl aryl heteroaryl; R?6 R7? each independently are hydrogen C?1-4?alkyl; R?2? halo, C?1-4?alkyl, hydroxyC1-4alkyl, C1-4alkyloxycarbonyl, carboxyl, formyl phenyl; R?3? C1-4alkyloxy; R?4? C1-4alkyloxy haloC1-4alkyl; Z -CH2-, -CH2-CH2-, -CH=CH-, -CHOH-CH2-, -O-CH2-, -C(=O)-CH2- -C(=NOH)-CH2-; -A-B- bivalent radical; A?1? C?1-6?alkanediyl, C1-6alkanediyl-oxy-C1-6alkanediyl, carbonyl, C1-6alkanediylcarbonyl, C1-6alkanediyloxy; A?2? bond C?1-6?alkanediyl; Q aryl. Processes for preparing said products, formulations comprising products their use as medicine disclosed, in particular inhibiting reversing effects multidrug resistance.