1 The Stress Response, Function of the Proteins, and Perspectives

摘要: This introductory chapter is divided into three sections. In the first section, we introduce nonspecialist to biology of stress response through a brief history early studies on or heat shock response. second highlight aspects response, including latest developments in field, with emphasis function proteins. Finally, third an attempt made place perspective human disease. Throughout this book, terms and will be used interchangeably. I. INTRODUCTORY REMARKS A. The Heat Shock Stress Response Living organisms respond at cellular level unfavorable conditions such as shock, other stressful situations many different origins, by rapid, vigorous, transient acceleration rate expression small number specific genes (heat genes). Consequently, products these (commonly referred proteins [hsps] proteins), which are also present under normal but lesser amounts, increase accumulate cells reach, some instances, fairly large concentrations. activation gene takes all only few exceptions, during embryonic development (Dura 1981; Wittig et al. 1983; Banerji 1984, 1987). A great deal circumstantial evidence supports belief that is...