Immunomodulatory Effects of Quercetin In Patient With Active Rheumatoid Arthritis

摘要: Rheumatoid arthritis is an autoimmune systemic inflammatory disease primarily affecting the joints as well other extra-articular tissues. This study was designed to evaluate immunomodulatory effect of different doses quercetin(500mg, 1000mg, 1500mg/day) for rheumatoid in patients treated with conventional modifying antirheumatic drugs (DMARDs). project performed on 160 who fulfilled American College Rheumatology (ACR) criteria diagnosis arthritis. In addition 30 healthy volunteers were invited participate and served a control group. The selected  allocated randomly into four groups, group (A) azathioprine(100 mg/day) plus placebo( starch containing capsules), (B) azathioprine (100mg/day) quercetin (500mg/day), (C) (1000mg/day) (D) azathioprine( 100mg/day) (1500mg/day). Serum level interleukin-6, interleukin-10, intercellular adhesion molecule I (ICAM-1), complements proteins pretreatment after eight weeks treatment. It found that at 1500mg/ day, when added 100mg , significantly(p< 0.05) reduced complement protein 3 (C3) & 4  (C4) levels elevated interleukin-10 level  more than had combined placebo or lower quercetin(500, 1000mg). However, all tested this able significantly (p< reduce molecule-1 compared quercetin-free Oral administration daily (500, 1000, 1500mg) combination 100 mg) produced action through reduction while elevating serum interleukine-10. Keywords : Immunomodulatory, Quercetin, Arthritis, Interleukins, Complements protein.