Enhanced scavenger receptor expression in monocyte-macrophages in dialysis patients
作者： Minoru Ando , Inger Lundkvist , Jonas Bergström , Bengt Lindholm
DOI: 10.1038/KI.1996.107
关键词:
摘要: Enhanced scavenger receptor expression in monocyte-macrophages dialysis patients. The macrophage (SR), which has two isoforms named type I and II, plays a leading role the atherosclerotic process. To elucidate mechanism of atherosclerosis patients, SR was studied from thirteen patients eight healthy controls. mRNA examined four hemodialysis controls matched for age sex. Monocytes were allowed to differentiate into macrophages vitro cultures seven days II analyzed with reverse transcription-polymerase chain reaction quantitated using radiation densities Southern blots. Only increased during differentiation accelerated by one or enhanced after five as compared detect protein expression, uptake fluorescently labeled acetylated low-density lipoprotein (Ac-LDL) evaluated flow cytometry. mean fluorescence intensity cells significantly higher continuous ambulatory peritoneal than controls, although number SR-positive remained constant. In conclusion, is probably up-regulation I, may contribute development these
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