Induction of acetylated low density lipoprotein receptor and suppression of low density lipoprotein receptor on the cells of human monocytic leukemia cell line (THP-1 cell).
作者： Hitoshi Hara , Hitoshi Tanishita , Shinji Yokoyama , Shoji Tajima , Akira Yamamoto
DOI: 10.1016/0006-291X(87)90601-2
关键词:
摘要: Abstract THP-1 cells, a human cell line established from acute monocytic leukemia degraded native low density lipoprotein (LDL) through LDL-specific pathway, but had no ability to degrade acetylated LDL. When the cells were treated with 12-o-tetradecanoylphorbol-13-acetate (TPA) differentiate into macrophage-like stage, those acquired LDL its specific pathway and lost Degradation of by differentiated was not reduced preincubation either or
elsevier.com
sci-hub.se 参考文章(15)
Gerrity Rg, The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. American Journal of Pathology. ,vol. 103, pp. 181- 190 ,(1981)
Joseph L. Goldstein, Michael S. Brown, Binding and Degradation of Low Density Lipoproteins by Cultured Human Fibroblasts COMPARISON OF CELLS FROM A NORMAL SUBJECT AND FROM A PATIENT WITH HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA Journal of Biological Chemistry. ,vol. 249, pp. 5153- 5162 ,(1974) , 10.1016/S0021-9258(19)42341-7
R. G. Gerrity, The role of the monocyte in atherogenesis: II. Migration of foam cells from atherosclerotic lesions. American Journal of Pathology. ,vol. 103, pp. 191- 200 ,(1981)
Keiya Tada, Tasuke Konno, Shigeru Tsuchiya, Shingi Nakae, Yasuko Kobayashi, Yoichi Goto, Hidesada Okumura, Induction of Maturation in Cultured Human Monocytic Leukemia Cells by a Phorbol Diester Cancer Research. ,vol. 42, pp. 1530- 1536 ,(1982)
B J Van Lenten, A M Fogelman, M M Hokom, L Benson, M E Haberland, P A Edwards, Regulation of the uptake and degradation of beta-very low density lipoprotein in human monocyte macrophages. Journal of Biological Chemistry. ,vol. 258, pp. 5151- 5157 ,(1983) , 10.1016/S0021-9258(18)32551-1
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Michael S. Brown, Joseph L. Goldstein, Regulation of the activity of the low density lipoprotein receptor in human fibroblasts Cell. ,vol. 6, pp. 307- 316 ,(1975) , 10.1016/0092-8674(75)90182-8
Shoji Tajima, Rikurou Hayashi, Shigeru Tsuchiya, Yasuko Miyake, Akira Yamamoto, Cells of a human monocytic leukemia cell line (THP-1) synthesize and secrete apolipoprotein E and lipoprotein lipase Biochemical and Biophysical Research Communications. ,vol. 126, pp. 526- 531 ,(1985) , 10.1016/0006-291X(85)90637-0
David W. Bilheimer, Shlomo Eisenberg, Robert I. Levy, The metabolism of very low density lipoprotein proteins I. Preliminary in vitro and in vivo observations Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. ,vol. 260, pp. 212- 221 ,(1972) , 10.1016/0005-2760(72)90034-3
Brian L. KNIGHT, Anne K. SOUTAR, Changes in the metabolism of modified and unmodified low-density lipoproteins during the maturation of cultured blood monocyte-macrophages from normal and homozygous familial hypercholesterolaemic subjects. FEBS Journal. ,vol. 125, pp. 407- 413 ,(1982) , 10.1111/J.1432-1033.1982.TB06698.X