Regulation of low density lipoprotein receptor activity in Chinese hamster ovary cells transfected with the c-fms gene
作者： Koji Yamamoto , Hitoshi Shimano , Toshimori Inaba , Takanari Gotoda , Kenji Harada
DOI: 10.1016/0014-5793(94)01242-3
关键词:
摘要: Chinese hamster ovary (CHO) cells were transfected with the human c-fms gene, which encodes receptor for macrophage colony-stimulating factor, to examine effects on low density lipoprotein (LDL) activity. Degradation of [125I]LDL was significantly reduced in CHO as compared non-transfected when incubated lipoprotein-deficient serum. Quantitative analysis LDL mRNA using a competitive PCR method demonstrated that suppression occurred at transcription. These findings suggest expression gene is involved regulation receptors macrophages.
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sci-hub.se 参考文章(19)
T. Gotoda, N. Yamada, T. Murase, T. Inaba, S. Ishibashi, H. Shimano, S. Koga, Y. Yazaki, Y. Furuichi, F. Takaku, Occurrence of multiple aberrantly spliced mRNAs upon a donor splice site mutation that causes familial lipoprotein lipase deficiency. Journal of Biological Chemistry. ,vol. 266, pp. 24757- 24762 ,(1991) , 10.1016/S0021-9258(18)54294-0
K Motoyoshi, F Takaku, H Mizoguchi, Y Miura, Purification and some properties of colony-stimulating factor from normal human urine Blood. ,vol. 52, pp. 1012- 1020 ,(1978) , 10.1182/BLOOD.V52.5.1012.1012
J.L. Goldstein, Y.K. Ho, M.S. Brown, T.L. Innerarity, R.W. Mahley, Cholesteryl ester accumulation in macrophages resulting from receptor-mediated uptake and degradation of hypercholesterolemic canine beta-very low density lipoproteins. Journal of Biological Chemistry. ,vol. 255, pp. 1839- 1848 ,(1980) , 10.1016/S0021-9258(19)85958-6
E R Stanley, P M Heard, Factors regulating macrophage production and growth. Purification and some properties of the colony stimulating factor from medium conditioned by mouse L cells. Journal of Biological Chemistry. ,vol. 252, pp. 4305- 4312 ,(1977) , 10.1016/S0021-9258(17)40265-1
S. Ishibashi, T. Inaba, H. Shimano, K. Harada, I. Inoue, H. Mokuno, N. Mori, T. Gotoda, F. Takaku, N. Yamada, Monocyte colony-stimulating factor enhances uptake and degradation of acetylated low density lipoproteins and cholesterol esterification in human monocyte-derived macrophages. Journal of Biological Chemistry. ,vol. 265, pp. 14109- 14117 ,(1990) , 10.1016/S0021-9258(18)77275-X
Charles J. Sherr, Carl W. Rettenmier, Rosalba Sacca, Martine F Roussel, A. Thomas Look, E. Richard Stanley, The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1 Cell. ,vol. 41, pp. 665- 676 ,(1985) , 10.1016/S0092-8674(85)80047-7
Martine F. Roussel, Thomas J. Dull, Carl W. Rettenmier, Peter Ralph, Axel Ullrich, Charles J. Sherr, Transforming potential of the c-fms proto-oncogene (CSF-1 receptor) Nature. ,vol. 325, pp. 549- 552 ,(1987) , 10.1038/325549A0
Eric Sariban, Thomas Mitchell, Donald Kufe, None, Expression of the c-fms proto-oncogene during human monocytic differentiation. Nature. ,vol. 316, pp. 64- 66 ,(1985) , 10.1038/316064A0
Johan H. Auwerx, Samir Deeb, John D. Brunzell, Reiling Peng, Alan Chait, Transcriptional activation of the lipoprotein lipase and apolipoprotein E genes accompanies differentiation in some human macrophage-like cell lines Biochemistry. ,vol. 27, pp. 2651- 2655 ,(1988) , 10.1021/BI00408A003
Hitoshi Hara, Hitoshi Tanishita, Shinji Yokoyama, Shoji Tajima, Akira Yamamoto, Induction of acetylated low density lipoprotein receptor and suppression of low density lipoprotein receptor on the cells of human monocytic leukemia cell line (THP-1 cell). Biochemical and Biophysical Research Communications. ,vol. 146, pp. 802- 808 ,(1987) , 10.1016/0006-291X(87)90601-2