Protective Effects of Butyric Acid in Colon Cancer

摘要: A great deal of evidence indicates that cancer is the result a reciprocal interaction between genetic susceptibility and environmental factors. Apparently, only 5% all cancers linked to genetic, inheritable alterations, while remainder associated with conditions act in concert individual susceptibility.1 In this context, dietary habit covers fundamental role. Following recent publication from American Institute for Cancer Research2 (AICR), “correct” diet could decrease rate by as much 20%. For some specific cancers, effect even more dramatic: 33 50% breast can be prevented through diet, 33% lung 75% colorectal are correct choices. Colorectal represents one well studied at molecular level: here, steps tumor progression show vivo an accumulation morphological changes mutations genes. Loss function APC suppressor gene causes hyperproliferation normal epithelium early adenoma; subsequent activation k-ras oncogene inactivation DCC p53 genes late adenoma carcinoma.3,4 very common causing over 50,000 deaths per year United States, 11% total cancer. They combined inherited factors stochastic mutations, partially related such composition.5 Considerable epidemiological data support hypothesis rich fiber decreased risk intestinal cancers.6,7 Although views appears simplistic remains controversial many aspects, it currently generally accepted. fact, fifteen recommendations AICR advises “eat variety vegetables fruits round”.2 Several mechanisms have been considered order explain protective (DF). include dilution luminal carcinogen concentration, fiber-associated colonic transit enterocyte exposure carcinogens, interactions contents, production tissue stimulation mucosa, role bile acids direct antineoplastic activity DF components.8–13 different mechanism which may modulate carcinogenesis butyric acid (BA), component short-chain fatty (SFCA) obtained degradation poorly fermented microflora. This review will focus on aspects affect BA models.