Local effects of limited recombination in Drosophila

摘要: Recent years have witnessed the integration of theoretical advances in population genetics with large-scale analyses complete genomes. As a result, growing number studies suggest frequent occurrence deleterious as well adaptive mutations. Given evidence for widespread selection, finite sizes natural populations, and limited recombination every genome, mutations under selection are expected to alter fate genetically linked The consequences this non-independent behavior can be described by Hill-Robertson effect terms reduction effective size (Ne). Reduction has two effects: 1) levels genetic variation 2) effectiveness that is manifested an increased probability fixation reduced advantageous Changes Ne previously been frequently associated changes rate also occur locally, association sites even when remains uniform. main objective work presented thesis investigate these local effects on patterns polymorphism divergence Drosophila using computer simulation experimental approaches. A approach developed estimates proportion substitutions McDonald-Kreitman framework. results high level unlikely remove all selection.