Dynamic thiol/disulphide homeostasis in patients with hypertrophic cardiomyopathy

摘要: In addition to the genetic complexity of hypertrophic cardiomyopathy (HCM), there must be other disease-modifying factors that contribute its highly variable clinical and phenotypic expression. The authors aimed investigate serum thiol/disulphide homeostasis as a proxy for oxidative stress using a novel automated assay in patients with HCM. This cross-sectional study was conducted on 119 HCM 52 without methods used measure dynamic calorimetric duplex quantities were developed 2014. Median native thiol levels significantly lower than those (312.5 μmol/L [285–370 μmol/L] vs 421 μmol/L [349–469.5 μmol/L]; p < 0.001). Serum total disulphide considerably control group ([844.68 ± 195.99 μmol/L 1158.92 ± 243.97 μmol/L; p < 0.001], [259.13 ± 65.66 μmol/L 375.02 ± 79.99 μmol/L; respectively). disulphide/native ratios disulphide/total controls (0.80 ± 0.09 0.92 ± 0.05; p < 0.001 0.31 [0.30–0.32] 0.32 [0.32–0.33]; Finally, reduced higher oxidized controls. Despite fact antioxidant capacity impaired, extracellular environment remained a reducing state by keeping low. Therefore, speculate may behave similarly tumours respect thiol-disulphide levels.