Tumoral Presentation of Amyloidosis (Amyloidomas) in Soft Tissues: A Report of 14 Cases

摘要: Amyloidosis in its diverse types (immunocytic dyscrasia-associated, reactive, or heredofamilial) most often presents a systemic form. Localized amyloidosis is uncommon general and exceedingly rare the soft tissues. The authors discuss cases of 14 patients whom manifested as localized mass ("amyloidoma") tissues (mostly mediastinal retroperitoneal), leading to clinical diagnosis neoplasm cases. On basis associated morphologically atypical phenotypically monoclonal cell population, resistance potassium permanganate pretreatment, lack reactivity with anti-AA antisera, 10 could be classified immunocytic dyscrasia-associated AL-amyloidosis. However, four had histopathologic histo- immunohistochemical characteristics reactive ("secondary") AA-amyloidosis. This proportion (28.5%) was higher than that suggested by sporadic AA-amyloidomas reported literature. pathologic distinction between these two categories important because appear have better prognosis.