Corazón y neoplasias
作者： Julia Calzas , Pilar Lianes , Hernán Cortés-Funes
DOI: 10.1016/S0300-8932(98)74751-7
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摘要: La afectacion cardiaca por enfermedades neoplasicas puede deberse a invasion el propio tumor, compresion del corazon y/o de los grandes vasos neoplasias extracardiacas, embolizacion y fundamentalmente efectos la terapeutica antitumoral. El tratamiento cancer ha experimentado un importante avance en las ultimas decadas gran expansion agentes quimioterapicos refinamiento tecnicas radioterapia; no obstante, muchos mas efectivos farmacos antineoplasicos irradiacion toracica ocasionan cardiotoxicidad aguda cronica. Asi, seguimiento largo plazo pacientes que han recibido antraciclinas, cruciales terapia muchas neoplasias, demuestra fallo cardiaco clinico 4,5 al 7% pacientes, incrementandose incidencia anomalias funcion con tiempo. Su patogenia probablemente incluya formacion radicales libres, alteraciones transporte calcio, disfuncion adrenergica o liberacion aminas vasoactivas. dexrazoxano es unico cardioprotector uso comercializado para grupo seleccionado carcinoma mama, lo necesario desarrollo nuevos protejan este reduzcan morbimortalidad secundaria mismos.
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