Expression and functional significance of tumor necrosis factor receptors in human myocardium.
作者： Guillermo Torre-Amione , Samir Kapadia , Joseph Lee , Roger D. Bies , Russel Lebovitz
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摘要: Background Tumor necrosis factor–α (TNF-α), a proinflammatory cytokine with potent negative inotropic properties, is elaborated in septic shock, acute myocarditis, reperfusion injury, and congestive heart failure. TNF-α acts by binding to two specific receptors: TNFR1 TNFR2. However, neither the presence nor significance of TNF receptors has been studied adult mammalian heart. Methods Results In present study, we showed that expresses mRNA receptor proteins for Moreover, immunohistochemical staining studies localized TNFR2 cardiac myocyte, providing potential signaling pathway deleterious effects TNF-α. The functional expression was explored use simple cell motion assay which assessed effect(s) mutants known bind selectively human We effect wild-type isolated feline myo...
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