Microbial ACBP/DBI-like genes are rare in the human gut microbiome and show no links with obesity

摘要: Acyl coenzyme A (CoA) binding protein (ACBP), also called diazepam-binding inhibitor (DBI), is a phylogenetically conserved that expressed by all eukaryotic species as well some bacteria. Since elevated ACBP/DBI levels play major role in the inhibition of autophagy, increase appetite, and enhanced lipid storage accompany obesity, we wondered whether produced human microbiome might affect host weight. We found genomes bacterial commensals rarely contain homologues, which are rather encoded pathogenic or environmental taxa were not prevalent feces. Exhaustive bioinformatic analyses 1,899 gut samples from healthy individuals refuted hypothesis body mass index (BMI) physiological context. Thus, regulation BMI unlikely to be affected microbial ACBP/DBI-like proteins. However, at speculative level, it remains possible potential bacteria enhance their virulence inhibiting autophagy hence subverting innate immune responses. IMPORTANCE (ACBP) can several organisms across domains life, including microbes, has shown roles metabolic processes. little known about its presence counterpart could metabolism. In present study, sequences multiple metagenomic data sets. Microbes carried included Saccharomyces cerevisiae, Lautropia mirabilis, Comamonas kerstersii, but these microorganisms associated with index, further indicating an unconvincing for