RNA sequencing-based analysis of gallbladder cancer reveals the importance of the liver X receptor and lipid metabolism in gallbladder cancer

摘要: Gallbladder cancer (GBC) is an aggressive malignancy. Although surgical resection may be curable, most patients are diagnosed at advanced unresectable disease stage. Cholelithiasis the major risk factor; however pathogenesis of disease, from gallstone cholecystitis to cancer, still not understood. To understand molecular genetic underpinnings this and explore novel therapeutic targets for GBC, we examined key genes pathways involved in GBC using RNA sequencing. We performed gene expression analysis 32 cases surgically-resected along with normal gallbladder tissue controls. observed that 519 were differentially expressed between GB mucosal The liver X receptor (LXR)/retinoid (RXR) farnesoid (FXR) /RXR top canonical GBC. Key these pathways, including SERPINB3 KLK1, overexpressed especially female patients. Additionally, ApoA1 suppressed as compared control tissues. LXR FXR genes, known important lipid metabolism also function tumor suppressors their down regulation appears critical pathogenesis. agonists have value potential targets.