Targeted Isolation of Xenicane Diterpenoids from Taiwanese Soft Coral Asterospicularia laurae.
作者： Jui-Hsin Su , Chia-Ching Liaw , Yuan-Bin Cheng , Hsueh-Wei Chang , Yi-Jen Chen
DOI: 10.3390/MD19030123
关键词:
摘要: Application of LC-MS/MS-based molecular networking indicated the ethanol extract octocoral Asterospicularia laurae is a potential source for discovery new xenicane derivatives. A natural product investigation this soft coral resulted in isolation four diterpenoids, asterolaurins O‒R (1‒4), together with six known compounds, xeniolide-A (5), isoxeniolide-A (6), xeniolide-B (7), 7,8-epoxyxeniolide-B (8), 7,8-oxido-isoxeniolide-A (9), and 9-hydroxyxeniolide-F (10). The structures isolated compounds were characterized by employing spectroscopic analyses, including 2D-NMR (COSY, HMQC, HMBC, NOESY) high-resolution electrospray ionization mass spectrometry (HRESIMS). Asterolaurin O first case brominated tricarbocyclic type floridicin family Xeniidae. Concerning bioactivity, cytotoxic activity those isolates was evaluated. As result, 1 2 demonstrated selective effect against MCF-7 cell line at IC50 14.7 25.1 μM, respectively.
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scilit.net参考文章(25)
Xuan Zhang, Abbas K. Samadi, Katherine F. Roby, Barbara Timmermann, Mark S. Cohen, Inhibition of cell growth and induction of apoptosis in ovarian carcinoma cell lines CaOV3 and SKOV3 by natural withanolide Withaferin A Gynecologic Oncology. ,vol. 124, pp. 606- 612 ,(2012) , 10.1016/J.YGYNO.2011.11.044
Mohamad B. Ksebati, Francis J. Schmitz, 24ξ-Methyl-5α-cholestane-3β,5,6β.22r.24-pentol 6-acetate: New polyhydroxylated sterol from the soft coral asterospicularia randalli. Steroids. ,vol. 43, pp. 639- 649 ,(1984) , 10.1016/0039-128X(84)90026-6
Ali A. H. El-Gamal, Shang-Kwei Wang, Chang-Yih Duh, Cytotoxic xenia diterpenoids from the soft coral Xenia umbellata. Journal of Natural Products. ,vol. 69, pp. 338- 341 ,(2006) , 10.1021/NP058093R
Tetsuo Iwagawa, Jun-ichi Kawasaki, Tsunao Hase, Jeffrey L.C. Wright, New di- and tricarbocyclic diterpenes possessing a bicyclic [4.3.1] ring system isolated from the soft coral, Xenia florida☆ Tetrahedron. ,vol. 53, pp. 6809- 6816 ,(1997) , 10.1016/S0040-4020(97)00316-5
J. C. Braekman, D. Daloze, B. Tursch, J. P. Declercq, G. Germain, M. van Meerssche, Chemical Studies of Marine Invertebrates. XXXIX. Three Novel Diterpenoids from the Soft Coral Xenia Novae-Britanniae†‡ Bulletin des Sociétés Chimiques Belges. ,vol. 88, pp. 71- 77 ,(2010) , 10.1002/BSCB.19790880111
Yoel Kashman, Amiram Groweiss, NEW DITERPENOIDS FROM THE SOFT CORALS XENIA MACROSPICULATA AND XENIA OBSCURONATA Journal of Organic Chemistry. ,vol. 45, pp. 3814- 3824 ,(1980) , 10.1021/JO01307A017
Tetsuo Iwagawa, Jun-ich Kawasaki, Tsunao Hase, Chao-Mei Yu, John A. Walter, Jeffrey L. C. Wright, A new tricarbocyclic diterpene structure from the soft coral Xenia florida Journal of The Chemical Society, Chemical Communications. pp. 2073- 2074 ,(1994) , 10.1039/C39940002073
Cristina Anta, Noemí González, Gilmar Santafé, Jaime Rodríguez, Carlos Jiménez, New Xenia diterpenoids from the Indonesian soft coral Xenia sp. Journal of Natural Products. ,vol. 65, pp. 766- 768 ,(2002) , 10.1021/NP010488X
Ali A. H. El-Gamal, Chin-Ying Chiang, Shin-Huei Huang, Shang-Kwei Wang, Chang-Yih Duh, Xenia diterpenoids from the formosan soft coral Xenia blumi. Journal of Natural Products. ,vol. 68, pp. 1336- 1340 ,(2005) , 10.1021/NP058047R
Darren Kessner, Matt Chambers, Robert Burke, David Agus, Parag Mallick, ProteoWizard: open source software for rapid proteomics tools development Bioinformatics. ,vol. 24, pp. 2534- 2536 ,(2008) , 10.1093/BIOINFORMATICS/BTN323