Pharmacokinetics and pharmacodynamics of danofloxacin in serum and tissue fluids of goats following intravenous and intramuscular administration.

摘要: Objective—To determine the pharmacokinetics and pharmacodynamics of danofloxacin in goats concentrations required to induce bacteriostasis, bactericidal activity, bacterial elimination. Animals—6 healthy British Saanen goats. Procedure—Danofloxacin (1.25 mg/kg body weight) was administered IV IM a cross-over design with 14 days between treatments. A tissue cage used for evaluation drug distribution into transudate exudate. The ex vivo antibacterial activity serum, exudate, against caprine isolate Mannheimia haemolytica determined. Pharmacokinetic pharmacodynamic data were integrated ratio area under concentration versus time curve minimum inhibitory (AUIC). Results—Elimination half-lives serum 4.67 4.41 hours after administration, respectively. Volume high administration via either route, bioavai...