Oral Muscle Relaxants for the Treatment of Chronic Pain Associated with Cerebral Palsy.

摘要: Purpose of review This is a comprehensive literature the available for treatment oral muscle relaxants cerebral palsy (CP) and associated chronic pain. It briefly describes background etiology pain in CP proceeds to weigh evidence relaxants. Recent findings permanent, chronic, non-progressive neuromuscular neurocognitive disorder motor dysfunction that diagnosed infancy frequently (62% patients) accompanied by or recurrent muscular Treatment crucial, focuses mostly on spasticity through non-interventional techniques, surgery medical treatment. Botulinum toxin injections provide temporary denervation, at cost repeated needle sticks. More recently, use has gained ground more are evaluate its efficacy. Common include baclofen, dantrolene diazepam. Baclofen commonly prescribed CP; however, despite year-long experience, there little support from controlled trials mixed. Dantrolene been used 30 years, very current exists use. Its efficacy usually impacted non-adherence due difficult dosing side-effects. Diazepam, benzodiazepine carries risks CNS depression as well addiction abuse. Evidence supporting dated, but recent short-term control enabling non-pharmacological interventions achieve long term benefit would otherwise not be tolerated. options cyclobenzaprine tizanidine. Cyclobenzaprine significant adverse events profile, including sedation; it was found effective, possible effective diazepam, currently FDA approved CP-related further required Tizanidine shown handful small studies. Summary Muscle an important adjunct therapy crucial pain, participation other forms treatments. exist their use, without risk research highlight proper dosing, co-treatments patient selection.