Cardiac troponin elevation predicts all-cause mortality in patients with acute exacerbation of chronic obstructive pulmonary disease: Systematic review and meta-analysis

摘要: Abstract Background Cardiovascular disease, especially ischemic heart is a major comorbidity in chronic obstructive pulmonary disease (COPD) patients. Several studies suggested that after acute exacerbation of COPD (AECOPD), there significant increase mortality (cardiac and all-cause) myocardial infarction. Whether cardiac troponin (Tn) elevation during AECOPD could be considered prognostic marker all-cause still debated. Methods To assess the role Tn AECOPD, we performed systematic review meta-analysis. We included with patients admitted to hospital for at least one assessment reporting relationship (after multivariable analysis) between mortality. Secondarily, were stratified according to: i) type (Tn I or T), ii) follow-up length (≤6months vs. >6months). Results Ten 8 Cardiac ranges from 18% 73%. found was significantly related an increased risk (OR 1.69; 95% CI 1.25–2.29; 2 40%). This finding independent (≤6months: OR 3.22; 1.31–7.91; >6months: 1.38; 1.02–1.86). Finally, T seems more helpful predicting as compared 1.54; 1.2–1.96 3.39, 0.86–13.36, respectively). Conclusions In emerged predictor