HLA-DQA1*1 contributes to resistance and A1*3 confers susceptibility to Type 1 (insulin-dependent) diabetes mellitus in Japanese subjects
作者： K. Yamagata , T. Hanafusa , H. Nakajima , M. Sada , H. Amemiya
DOI: 10.1007/BF00500386
关键词:
摘要: In this study HLA-DQA1 and TNF genes in addition to HLA-DQB1 gene were investigated at DNA level for elucidation of the genetic backgrounds Type 1 (insulin-dependent) diabetes mellitus Japanese subjects. DNA, amplified by polymerase chain reaction, was subjected allele specific oligonucleotide dot blot analysis, restriction fragment length polymorphism analysis or sequencing. Polymorphism NcoI did not correlate with patients. DQw1.2 had a protective effect against disease, DQA1*1 significantly decreased DQA1*3 increased. Seventeen out twenty-two diabetic patients (77%) homozygous five (23%) heterozygous. The normal nucleotide sequence. Furthermore, found unexpectedly two without DR4 DR9. These data indicate that DQA1 confers susceptibility resistance
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