Matrix metalloproteinases in the pathogenesis of asthma and COPD: implications for therapy.

摘要: While asthma is an inflammatory disorder of the airways involving mediators released from mast cells and eosinophils, inflammation alone insufficient to explain chronic nature disease. Recent progress in understanding disease pathogenesis has revealed that airway remodeling, which at least part due excess extracellular matrix (ECM) deposition wall, plays a significant role airflow obstruction. Matrix metalloproteinases (MMPs) have been suggested be major proteolytic enzymes induce remodeling COPD. It widely accepted different processes are involved COPD with cells, mediators, responses treatments. Despite these processes, obstruction characterize two diseases. MMP-2 -9 reported both diseases MMP-12, addition MMPs, In this review, we discuss current views on MMPs bronchial Anti-MMP therapy could theoretically useful prevent However, date no clinical data available regarding efficacy anti-MMP therapies treatment patients